Institut für Komplementäre und Integrative Medizin


Wolf Ursula, Prof. Dr. med.


Anthroposophisch erweiterte Medizin

0041 31 631 81 40
Universität Bern
Institut für Komplementäre und Integrative Medizin
Fabrikstrasse 8
3012 Bern
Ambulante Patienten/Konsilien auf Stationen des Inselspitals
Telefon 0041 31 632 66 41
Fax 0041 31 632 66 44

Prof. Dr. Wolf is director at the Institute of Complementary Medicine at the University of Bern. She holds a FMH diploma in general internal medicine and anthroposophically extended medicine. Prof. Dr. Wolf has worked as a postdoctoral research associate in biomedical optics at the Dept. of Physics at the University of Illinois at Urbana-Champaign, USA, one of the top ten universities for physics in the USA and 4 months as Visiting Scientist at the National High Magnetic Field Laboratory at Tallahassee, Florida, USA. Within the Swiss Governmental „Program Evaluation Complementary Medicine” she was responsible for compiling Health Technology Assessments for several complementary medicinal disciplines. Her professional activities at the university include research, teaching and patient care. Her overall research aim is investigating and further developing complementary medicine with quantitative and qualitative state-of-the-art methods.

Prof. Dr. Wolf is president elect of the International Society for Complementary Medicine Research ISCMR.

Publications in international peer-reviewed scientific journals

  1. von Bonin D, Klein SD, Würker J, Streit E, Avianus O, Grah C, Salomon J, Wolf U. Speech-guided breathing retraining in asthma - a randomised, controlled cross-over trial in real-life outpatient settings. Trials, in press
  2. Kloter E, Barrueto K, Klein SD, Scholkmann F, Wolf U. Heart Rate Variability as a Prognostic Factor for Cancer Survival – A Systematic Review. Frontiers in Physiology, section Clinical and Translational Physiology. doi: 10.3389/fphys.2018.00623, in press
  3. Nasseri N, Kleiser S, Wolf U, Wolf M. Tissue oximetry by diffusive reflective visible light spectroscopy: Comparison of algorithms and their robustness. Journal of Biophotonics. 2018 Mar 25:e201700367. doi: 10.1002/jbio.201700367. [Epub ahead of print]
  4. Klein SD, Würtenberger S, Wolf U, Baumgartner S, Tournier A. Physicochemical Investigations of Homeopathic Preparations: A Systematic Review and Bibliometric Analysis – Part 1. J Altern Complement Med. 2018 Jan 29. doi: 10.1089/acm.2017.0249. Epub 2018 Jan 29.
  5. Scholkmann F, Hafner T, Metz AJ, Wolf M, Wolf U. Effect of short-term colored-light exposure on cerebral hemodynamics and oxygenation, and systemic physiological activity. Neurophotonics. 2017 Nov 20. doi: 10.1117/1.NPh.4.4.045005.
  6. Klein SD, Kohler S, Krüerke D, Templeton A, Weibel A, Haraldsson E, Nahm M, Wolf U. Erfahrungen am Lebensende: Eine Umfrage bei Ärzten und Pflegenden eines Spitals für anthroposophisch erweiterte Medizin. Complement Med Res. 2017 Oct 26. doi: 10.1159/000478090. Epub 2017 Oct 26.
  7. Marszalek G, Torchetti L, Barth J, Wolf U, Frei-Erb M. Einstellung von Ärzten gegenüber Komplementärmedizin in einer ländlichen Region der Schweiz: Ergebnisse  einer Umfrage. Complement Med Res. 2017 Sep 7. doi: 10.1159/000480332. [Epub ahead of print] German.
  8. Metz AJ, Klein SD, Scholkmann F, Wolf U. Continuous coloured light altered human brain haemodynamics and oxygenation assessed by systemic physiology augmented functional near-infrared spectroscopy. Sci Rep. 2017 Aug 30;7(1):10027. doi: 10.1038/s41598-017-09970-z
  9. Metz AJ, Klein SD, Scholkmann F, Wolf U. Physiological effects of continuous colored light exposure on Mayer wave activity in cerebral hemodynamics:  – A functional near-infrared spectroscopy (fNIRS) study. Adv Exp Med Biol. 2017;977:277-283. doi: 10.1007/978-3-319-55231-6_38
  10. Hoffmann A, Klein SD, Gründemann C, Garcia-Käufer M, Wolf U, Huber R. Efficacy of a Nasal Spray from Citrus limon and Cydonia oblonga for the Treatment of Hay Fever Symptoms-A Randomized, Placebo Controlled Cross-Over Study. Phytother Res. 2016 Sep;30(9):1481-6.
  11. Caldwell M, Scholkmann F, Wolf U, Wolf M, Elwell C, Tachtsidis I. Modelling confounding effects from extracerebral contamination and systemic factors on functional near-infrared spectroscopy. Neuroimage. 2016 Aug 31. pii: S1053-8119(16)30450-5. doi: 10.1016/j.neuroimage.2016.08.058. Epub 2016 Aug 31.
  12. Klein SD, Wolf U. Comparison of homeopathic globules prepared from high and ultra-high dilutions of various starting materials by ultraviolet light spectroscopy. Complement Ther Med. 2016 Feb;24:111-7. doi: 10.1016/j.ctim.2015.12.017.
  13. Klein SD, Torchetti L, Frei-Erb M, Wolf U. Usage of complementary medicine in Switzerland: Results of the Swiss Health Survey 2012 and development since 2007. PLoS One. 2015 Dec 9;10(12):e0144676. doi: 10.1371.
  14. Von Bonin D, Grote V, Buri C, Cysarz D, Heusser P, Moser M, Wolf U, Laederach K. Adaption of cardio-respiratory balance during day-rest compared to deep sleep - an indicator for quality of life? Psychiatry Res. 2014 Nov 30;219(3):638-44. doi: 10.1016/j.psychres.2014.06.004.
  15. Klein SD, Bayard C, Wolf U. The Alexander Technique and musicians: a systematic review of controlled trials. BMC Complement Altern Med. 2014 Oct 24;14(1):414.
  16. Holper L, Gross A, Scholkmann F, Humphreys BK, Meier ML, Wolf U, Wolf M, Hotz-Boendermaker S Physiological effects of mechanical pain stimulation at the lower back measured by functional near-infrared spectroscopy and capnography. J Integr Neurosci. 2014 Mar;13(1):121-42. doi: 10.1142/S0219635214500071. Epub 2014 Mar 24.
  17. Scholkmann F, Klein SD, Gerber U, Wolf M, Wolf U. Cerebral hemodynamic and oxygenation changes induced by inner and heard speech – a study combining functional near-infrared spectroscopy and capnography. J Biomed Opt. 2014 Jan;19(1):17002. doi: 10.1117/1.JBO.19.1.017002.
  18. Scholkmann F, Holper L, Wolf U, Wolf M. A new methodical approach in neuroscience: assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning. Front Hum Neurosci. 2013 Nov 27;7:813. doi: 10.3389/fnhum.2013.00813. Review.
  19. Scholkmann F, Kleiser S, Metz A, Zimmermann R, Pavia JM, Wolf U, Wolf M. A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology. Neuroimage. 2013 May 16. doi:pii: S1053-8119(13)00494-1. 10.1016/j.neuroimage.2013.05.004.
  20. Scholkmann F, Wolf M, Wolf U. The effect of inner speech on arterial CO2, cerebral hemodynamics and oxygenation – A functional NIRS study. Adv Exp Med Biol. 2013;789:81-7.
  21. Klein SD, Sandig A, Baumgartner S, Wolf U. Differences in median ultraviolet light transmissions of serial homeopathic dilutions of copper sulfate, Hypericum perforatum and sulfur. Evid Based Complement Alternat Med. 2013, Article ID 370609, doi:10.1155/2013/370609.
  22. Scholkmann F, Gerber U, Wolf M, Wolf U. End-tidal CO(2). An important parameter for a correct interpretation in functional brain studies using speech tasks. Neuroimage. 2012;66:71-79.
  23. Klein SD, Frei-Erb M, Wolf U. Usage of complementary medicine across Switzerland. Results of the Swiss Health Survey 2007. Swiss Med Wkly. 2012;142:w13666.
  24. Klein SD, Becker S, Wolf U. Occurrence of Chai Hu (Bupleuri Radix) in Prescriptions of Chinese Herbal Medicine in Switzerland. Forsch Komplementmed. 2012;19(5):242-6.
  25. Weinzirl J, Wolf M, Nelle M, Heusser P, Wolf U. Colored light and brain and muscle oxygenation. Adv Exp Med Biol. 2012;737:33-6.
  26. Wolf U, Toronov V, Choi JH, Gupta R, Michalos A, Gratton E, Wolf M. Correlation of functional and resting state connectivity of cerebral oxy-, deoxy-, and total hemoglobin concentration changes measured by near-infrared spectrophotometry. J. Biomed. Opt. 2011;16, 087013.
  27. Wolf U, Scholkmann F, Rosenberger R, Wolf M, Nelle M. Changes in hemodynamics and tissue oxygenation saturation in the brain and skeletal muscle induced by speech therapy - A near infrared spectroscopy study. TheScientificWorldJournal. 2011;11:1206-1215.
  28. Weinzirl J, Wolf M, Heusser P, Nelle M, Wolf U. Effects of changes in colored light on brain and calf muscle blood concentration and oxygenation. TheScientificWorldJournal. 2011;11:1216-1225.
  29. Jäger J, Scherr C, Wolf U, Simon M, Heusser P, Baumgartner S. Investigation of arsenic stressed yeast (Saccharomyces cerevisiae) as bioassay for use in homeopathic basic research. ScientificWorldJournal. 2011 March 7;11:568-83.
  30. Wolf M, von Bonin D, Wolf U. Speech therapy changes blood circulation and oxygenation in the brain and muscle. A near-infrared spectrophotometry study. Adv Exp Med Biol. 2011;701:21-5.
  31. Marschollek B, Nelle M, Wolf M, Baumgartner S, Heusser P, Wolf U. Effects of exposure to physical factors on homeopathic preparations as determined by ultraviolet light spectroscopy. ScientificWorldJournal. 2010 Jan 8;10:49-61.
  32. Baumgartner S, Wolf M, Skrabal P, Bangerter F, Heusser P, Thurneysen A, Wolf U. High-field 1H T(1) and T(2) NMR relaxation time measurements of H2O in homeopathic preparations of quartz, sulfur, and copper sulfate. Naturwissenschaften. 2009 Sep;96(9):1079-89.
  33. Wolf U, Wolf M, Heusser P, Thurneysen A, Baumgartner S. Homeopathic Preparations of Quartz, Sulfur and Copper Sulfate Assessed by UV-Spectroscopy. Evid Based Complement Alternat Med. 2009 May 27.
  34. Heusser P, Berger S, Stutz M, Hüsler A, Haeberli A, Wolf U. Efficacy of homeopathically potentized antimony on blood coagulation. A randomized placebo controlled crossover trial. Forsch Komplementmed. 2009 Feb;16(1):14-8.
  35. Wolf M, Morren G, Haensse D, Karen T, Wolf U, Fauchère JC, Bucher HU. Near infrared spectroscopy to study the brain: an overview. Opto-Electron. Rev. 2008;16(4): 413-419.
  36. Heusser P, Wolf U, Vonwiller HM, Messerli N, Laederach-Hofmann K. Nutrition with “light and water”? In strict isolation for 10 days without food. A critical case study. Forsch Komplementmed. 2008;15(4): 203-209.
  37. Wolf U, Wolf M, Choi JH, Paunescu LA, Michalos A, Gratton E. Regional differences of hemodynamics and oxygenation in the human calf muscle detected by near infrared spectrophotometry. J Vasc Interv Radiol. 2007 Sep;18(9):1094-101.
  38. Bornhoft G, Maxion-Bergemann S, Wolf U, Kienle GS, Michalsen A, Vollmar HC, Gilbertson S, Matthiessen PF. Checklist for the qualitative evaluation of clinical studies with particular focus on external validity and model validity. BMC Medical Research Methodology. 2006;6:56.
  39. Wolf U, Maxion-Bergemann S, Bornhoft G, Matthiessen PF, Wolf M. Use of complementary medicine in Switzerland. Forsch Komplementmed. 2006;13 Suppl 2:4-6.
  40. Maxion-Bergemann S, Bornhoft G, Sonderegger E, Renfer A, Matthiessen PF, Wolf U. Traditional chinese medicine (phytotherapy): health technology assessment report - selected aspects. Forsch Komplementmed. 2006;13 Suppl 2:30-41.
  41. Maxion-Bergemann S, Wolf M, Bornhoft G, Matthiessen PF, Wolf U. Complementary and alternative medicine costs - a systematic literature review. Forsch Komplementmed. 2006;13 Suppl 2:42-5.
  42. Bornhoft G, Wolf U, Ammon K, Righetti M, Maxion-Bergemann S, Baumgartner S, Thurneysen AE, Matthiessen PF. Effectiveness, safety and cost-effectiveness of homeopathy in general practice - summarized health technology assessment.  Forsch Komplementmed. 2006;13 Suppl 2:19-29. Epub 2006 Jun 26.
  43. Gratton E, Toronov V, Wolf U, Wolf M, Webb A. Measurement of brain activity by near-infrared light. J Biomed Opt. 2005 Jan-Feb;10(1):11008.
  44. von Siebenthal K, Keel M, Fauchère JC, Dietz V, Haensse D, Wolf U, Helfenstein U, Bänziger O, Bucher HU, Wolf M. Variability of cerebral hemoglobin concentration in very preterm infants during the first 6 hours of life. Adv. Exp. Med. Biol. 2005;566:91-7.
  45. Safonova LP, Michalos A, Wolf U, Wolf M, Hueber DM, Choi JH, Gupta R, Polzonetti C, Mantulin WW, Gratton E. Age-correlated changes in cerebral hemodynamics assessed by near-infrared spectroscopy. Archives of Gerontology and Geriatrics. 2004;39(3):207-25.
  46. Choi JH, Wolf M, Toronov V, Wolf U, Polzonetti C, Hueber D, Safonova LP, Gupta R, Michalos A, Mantulin WW, Gratton E. Noninvasive determination of the optical properties of the adult brain: Near-infrared spectroscopy approach. J. Biomed. Opt. 2004;9(1):221-229.
  47. Morren G, Wolf M, Lemmerling P, Wolf U, Choi JH, Gratton E, De Lathauwer L, Van Huffel S. Detection of fast neuronal signals in the motor cortex from functional near infrared spectroscopy measurements using independent component analysis. Med Biol Eng Comput. 2004;42:92-99.
  48. Wolf U, Wolf M, Choi JH, Levi M, Choudhury D, Hull S, Coussirat D, Paunescu LA, Safonova LP, Michalos A, Mantulin WW, Gratton E. Localized irregularities in hemoglobin flow and oxygenation in the calf muscle in patients with peripheral vascular disease detected by near-infrared spectrophotometry. Vasc. Surg. 2003;37(5):1017-1026.
  49. Wolf U, Wolf M, Choi JH, Paunescu LA, Michalos A, Safonova L, Gratton E. Mapping of hemodynamics with near infrared spectroscopy of the human calf tissue and the influence of the adipose tissue thickness. Adv. Exp. Med. Biol. 2003;510:225-230.
  50. Wolf M, Wolf U, Choi JH, Toronov V, Paunescu LA, Michalos A, Gratton E. Fast cerebral functional signal in the 100ms range detected in the visual cortex by frequency-domain near-infrared spectroscopy. Psychophysiology. 2003;40(4):521-528.
  51. Safonova LP, Michalos A, Wolf U, Choi JH, Wolf M, Mantulin WW, Hueber DM, Gratton E. Diminished cerebral circulatory autoregulation in obstructive sleep apnea investigated by near-infrared spectroscopy. Sleep Research Online ( 2003;5(4):123-132.
  52. Wolf M, Franceschini MA, Paunescu LA, Toronov V, Michalos A, Wolf U, Gratton E, Fantini S. Absolute frequency-domain pulse oxymetry of the brain: Methodology and measurements. Adv. Exp. Med. Biol. 2003;536:61-74.
  53. Wolf M, Wolf U, Choi JH, Gupta R, Safonova LP, Paunescu LA, Michalos A, Gratton E. Detection of the fast neuronal signal on the motor cortex using functional frequency domain near infrared spectroscopy. Adv. Exp. Med. Biol. 2003;510:193-197.
  54. Wolf M, Franceschini MA, Paunescu LA, Toronov V, Michalos A, Wolf U, Gratton E, Fantini S. Absolute frequency-domain pulse oximetry of the brain: methodology and measurements. Adv Exp Med Biol. 2003;530:61-73.
  55. Wolf M, Wolf U, Choi JH, Gupta R, Safonova LP, Paunescu LA, Michalos A, Gratton E. Functional Frequency-domain Near-infrared Spectroscopy Detects Fast Neuronal Signal in the Motor Cortex. Neuroimage. 2002;17:1868-1875.
  56. Wolf M, Wolf U, Toronov V, Michalos A, Paunescu LA, Choi JH, Gratton E. Different Time Evolution of Oxyhemoglobin and Deoxyhemoglobin Concentration Changes in the Visual and Motor Cortex during Functional Stimulation: A Near Infrared Spectroscopy Study. Neuroimage. 2002;16:704-712.
  57. Toronov V, Webb A, Choi JH, Wolf M, Safonova L, Wolf U, Gratton E. Study of local cerebral hemodynamics by frequency-domain near-infrared spectroscopy and correlation with simultaneously acquired functional magnetic resonance imaging. Optics Express. 2001;9(8):417-427.
  58. Wolf M, Keel M, Schenk D, Dietz V, von Siebenthal K, Wolf U, Baenziger O, Bucher HU. Comparison of Absolute Cerebral Haemoglobin Concentration in Neonates Measured Directly and by the Oxygen Swing Method Both Based on Near Infrared Spectrophotometry. Adv Exp Med Biol. 1998;454:125-129.